Co-organizors  :

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Welcome to International Symposium on Organic Synthesis and Drug Development 2008

Symposium Program of ISODD2008

 

  AM Session PM Session Eve Session All Day
Tue
Oct 14
Booth set up by Exhibitors
Registration from 9 am to 7 pm
Opening 
&
Welcome Reception 
6 pm to 9 pm
 
Wed
Oct 15
Plenary lectures
&
Exhibition Opens
Invited lectures
&
Poster Presentations
Poster Presentations 
(workshop)
Exhibition
Mini Trip (optional)
Thu
Oct 16
Plenary lectures Invited lectures
&
Poster Presentations
Poster Presentations Mini Trip (optional)
(workshop)
Exhibition 
Mini Trip (optional)
Fri
Oct 17
Invited lectures
&
Poster Presentations
Invited lectures
&
    Keynote     Speaker
Closing 
&
Conference Dinner
Exhibition (Tear down from 2 pm)
Mini Trip (optional)
Sat
Oct 18
Departure after breakfast
Optional Post-Conference Tours A, B, C, D (the price is not include the registration fee) 

 

 Schedule of ISOSDD’08 Technical Program

 Day 1-  October 14, 2008, Tuesday

8:30 - 18:00

Arrival and Registration (Main hall of Zhongshan Hotel)

18:00 - 21:00

Welcome

Opening Ceremony and Reception Banquet

(First floor of Main Building)

Guo-Qiang Lin, Rao Rapaka, Yi Pan

Plenary Lecture 01

ChiarmanMingde Xia (SAPA)

Stephen Scypinski (Bristol-Myers Squibb)

Overview of the Drug Development Process: Assuring Product Quality and Efficacy

 

 

  

Day 2- October 15, 2008 – Wednesday morning

8:00 - 8:30

Welcome

Opening Ceremony (Huangpu Hall of the hotel)

Guo-Qiang Lin, Yi Pan, Jun Chen (President of NJU), Mingde Xia (SAPA)

Chairman: Biao Jiang (SIOC, CAS)

8:30 - 9:15

Plenary Lecture 02

 

Philip S. Portoghese (University of Minnesota)

Ligands that activate heterodimeric opioid receptors: functional and clinical relevance

9:15 - 10:00

Plenary Lecture 03

 

Xiyan Lu (Shanghai Institute of Organic Chemistry, CAS)

Paladium(II) catalyzed addition of arylboronic acids to carbon-heteroatom multiple bonds. An enantioselective, catalytic Grignard type reaction

10:00 - 10:20

Coffee Break

Chairman: Lutz F. Tietze (Universität Göttingen)

10:20 - 11:05

Plenary Lecture 04

Mauricio Futran (Bristol-Myers Squibb)

Knowledge Creation in Pharmaceutical Process Development in the Context of Global Partnerships

11:05 - 11:50

Plenary Lecture 05

Chen Li ( Roche-China)

Regulation of Signals through Protein-Protein Interaction: 15 years and counting

11:50 - 12:35

Plenary Lecture 06

Peter W. Schiller (Clinical Research Institute of Montreal, Canada)

Use of Novel Amino Acid Analogues in the Development of Peptides as Drugs or Pharmacological Tools

12:35-1400

Lunch

 

Day 2- October 15, 2008 – Wednesday afternoon

Session 1: Organic Synthesis I ( Hall A)

Chairman: Rengxiang Tan (Nanjing Univ.)

14:00–14:30

Inivted Lecture 01

Dawei Ma (SIOC, CAC)

Amino Acid Promoted Ullmann-type Coupling Reactions and Their Applications in Organic Synthesis

14:30 –15:00

 

Inivted Lecture 02

Scott Snyder (Columbia University)

Achieving Synthetic Control When Nature Abandons Selectivity

15:00-15:30

Inivted Lecture 03

Zhenfeng Xi (Peking Univ.)

Synthesis of multiply substituted pyrrolopyridiens, pyridines and pyrroles

15:30–16:00

Inivted Lecture 04  

Biao Jiang (Shanghai Institute of Organic Chemistry, CAS)

Synthesis of Chiral Gossypol and Their Derivatives and Evaluation of Their Anticancer Activity

16:00–16:20

Coffee Break

Chairman: Robert Shaw (Texas Tech University)

16:20–16:50

Inivted Lecture 05

Lutz F. Tietze (Universität Göttingen)

A New Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibody-Enzyme Conjugates

16:50-17:20

Inivted Lecture 06

Meixiang Wang (Insitute of Chemsitry, CAS)

Enantioselective Nitrile Biotransformations and Their Applications in the Synthesis of Natural and Bioactive Compounds

17:20-17:50

Inivted Lecture 07

LiMing Zhang (University of Nevada, Reno)

Au-Catalyzed Cycloaddition Reactions

 

Day 2- October 15, 2008 – Wednesday afternoon

Session 2(a):Medicinal Chemistry Approaches to Tackling Cardiovascular and Metabolic Diseases (Hall B)

Chairman: P.K Jadhav (Eli Lilly & Company, Indianapolis) / Martin Procter (Prosidion, UK)

14:00–14:30

Inivted Lecture 08

Jiesheng Kang (Sanofi Aventis, USA)

HERG and the LQT Syndrome: Background, Regulations & Non-Clinical Strategy

14:30 –15:00

Inivted Lecture  09

Donald Pinto (Bristol-Myers Squibb Company, USA)

A Next Generation Oral Anticoagulant: The Discovery of Apixaban, a Potent, Selective and Orally Bioavailable Factor Xa Inhibitor

15:00-15:30

Inivted Lecture 10

P. K. Jadhav  (Eli Lilly & Company, USA)

Orally bioavailable, nonsteroidal MR antagonist LY2180176 for the treament of hypertension

15:30-15:50

Coffee Break

  

Session 3: Medicinal Chemistry Approaches to Tackling Oncology Disease ( Hall B)

Chairman: Joe ShihLilly Research Laboratories, Eli Lilly and Company, USA)

15:50–16:20

Inivted Lecture 11 

 

Qun  Li (Chief Scientific Officer, Egret Pharma, Shanghai, China)                              

Design and Synthesis of Orally Bioavailable Akt Kinase (PKB) Inhibitors as Anticancer Agents

16:20–16:50

Inivted Lecture 12 

 

Jim Henry (Discovery Chemistry Research and Technologies, Lilly Research Laboratories, Eli Lilly and Company, USA)

Type II Kinase Inhibitors for the Treatment of Cancer

16:50-17:20

Inivted Lecture 13

 

Shawn Qian   (Associate Director, Meidcinal Chemistry, Cytokinetics, Inc., USA)

Discovery of Mitotic Kinesin Inhibitors as Novel Anticancer Agents

17:20-17:50

Inivted Lecture 14

 

Joe Shih Lilly Research Laboratories, Eli Lilly and Company,  USA)

The Evolution of Lilly Oncology: From Cytotoxic Agents (Discovery and Development of ALIMTAÒ) to Kinase Inhibitors

 

Day 2- October 15, 2008 – Wednesday afternoon

Session 4: Pharmaceutical Development ( Hall C)

Chairman: Jianji Wang (Bristol-Myers Squibb Company)

14:00–14:30

Inivted Lecture 15

Robert Discordia (Director, Department of Process Research and Development, Bristol-Myers Squibb Company)

The Process Development of an MMP Inhibitor: Development and Execution of a Crystallization Induced Dynamic Resolution

14:30 –15:00

Inivted Lecture  16

Jason Huang (Senior Research Investigator II, Department of Analytical Research and Development, Bristol-Myers Squibb Company)

Analytical Role in Pharmaceutical Development and GMP Compliance

15:00-15:30

Inivted Lecture 17

Joan Ruan (Group Leader, Department of Analytical Research and Development, Bristol-Myers Squibb Company)

Forced Degradation Strategy

15:30-16:00

Inivted Lecture 18

Thomas Colacot (Johnson Matthey Catalyst)

Highly Active, Air-Stable Pd Catalysts for Challenging Cross-Coupling Reactions

16:00–16:20

Coffee Break

 

Chairman: Mingde Xia (SAPA)

16:20–16:50

Inivted Lecture 19 

Jianji Wang (Senior Research Investigator II, Department of Process Research and Development, Bristol-Myers Squibb Company)

Pharmaceutical Process Research and Development

16:50-17:20

Inivted Lecture 20

Xiongwei Shi (United Pharmatech)

 

Sundia's Strategies and Steps towards Meeting Client's Requirements for Outsourcing Services

17:20-17:50

Inivted Lecture 21

Jay (Jiefei) Cheng (Otsuka Maryland Medicinal Laboratories Inc, USA)

TheYin and Yang of theFattyAcid Oxidation Modulation

 

17:50-19:00

Dinner

19:00-22:00

Posters

   

Day 3-  October 16, 2008– Thursday Morning

Plenary Lecture:

(Huangpu Hall of the Hotel)

Chairman: Zhenfeng Xi (Peking Univ.)

8:00 – 8:45

Plenary Lecture 07

Kevin Burgess (Texas A&M University)

Libraries of Bivalent Peptidomimetics for Mimicking or Disrupting Protein-Protein Interactions

8:45–9: 30

Plenary Lecture 08

Guo-Qiang Lin (SIOC, CAS and NSFC)

New Synthetic Methodologies and Their Utilities in the Synthesis of Bio-active Products

9:30 -10:15

Plenary Lecture 09

Bruce Lipshutz (University of California, Santa Barbara)

Green Chemistry Using "Designer" Surfactants. Just Add Water

10: 15 – 10:45

Coffee Break

 

Chairman

Dawei Ma (SIOC, CAS)

10:45 - 11:30

Plenary Lecture 10

Rene Imwinkelried (Schering-Plough, USA)

Chemical Process Scale-Up Opportunities

11:30 -12:15

Plenary Lecture 11

Ralph P Volante (Lushi Tan) (Process Research, Merck)

Asymmetric hydrogenation/transfer hydrogenation a powerful strategy for drug synthesis

12:15– 14:00

Lunch

  

Day 3-  October 16–Thursday afternoon

Session 5: General Medicinal Chemistry  (Hall A)

Chairman: Qidong You (China Pharmaceutical University)/Jianhe Deng (GlaxoSmithKline. Co)

14:00–14:30

 

Inivted Lecture 22

Jianhe Deng (GlaxoSmithKline. Co)

Encoded Library Technology: A New Methodology for Lead Discovery

14:30 –15:00

Inivted Lecture  23

Robert Shaw (Texas Tech University)

Antibiotic resistance in bacteria: novel metalloenzyme inhibitors

15:00-15:30

Inivted Lecture 24

Ao Zhang (Shanghai Institute of Materia Medica, CAS)

Multi-Strategy for Design of Dopamine D1 & Serotonin 5-HT1A Receptor Ligands.

15:30–16:00

Inivted Lecture 25  

Qidong You (China Pharmaceutical University)

Conformation-based design of camptothecin analogues as potent DNA topoisomerase I inhibitors

  

Day 3-  October 16–Thursday afternoon

Session 2(b) :Medicinal Chemistry Approaches to Tackling Cardiovascular and Metabolic Diseases (Hall B)

Chairman: P.K Jadhav (Eli Lilly & Company, Indianapolis) / Martin Procter (Prosidion, UK)

14:00–14:30

Invited Lecture 26

Wenqing Yao (Incyte Corporation, USA)

Discovery of Potent and Selective 11ßHSD1 Inhibitors: Scaffold Hoping Approach for Novel Lead Generation Based on Medchem Intuition

14:30 –15:00

Inivted Lecture  27

Gang Zhao (Abbott, USA)

Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators

15:00-15:30

Inivted Lecture 28

Martin Procter (Prosidion, UK)

Design and synthesis of orally bioavailable Glucokinase activators

15:30–16:00

Inivted Lecture 29  

Hongke Liu  (Nanjing Normal University)

Interactions of Organometallic Ruthenium Arene anticancer Complexes with DNA

 

Day 3-  October 16–Thursday afternoon

Session 6: Chemistry Application in Pharmaceutical Industry ( Hall C)

Chairman: Hua Marlon, Zhong (Jiangyin PharmaAdvance, Inc.)

14:00–14:30

Inivted Lecture 30

Joseph M. Salvino (Director, Hit to Lead Chemistry, Cephalon, Inc)

Practical Approaches toward Lead Finding and Lead Optimization Library Synthesis

14:30 –15:00

Inivted Lecture  31

Yonghui Wang (Medicinal Chemistry, Oncology CEDD, GlaxoSmithKline, USA)

7TM Receptor Antagonists: Lead Discovery Strategy and Case Studies

15:00-15:30

Inivted Lecture 32

Paul (Peng) Guo (President, AstaTech, Inc,USA)

Process Technology Commercialization: From Target to Technology Development

15:30–16:00

Inivted Lecture 33 

Maotang Zhou (Chiral Quest (China), Suzhou Industrial Park)

Advances in Asymmetric Hydrogenation: From Innovative Ligands to Commercial Manufacture

  

16:00–18:00

Visit High-tech Zone

 

18:00-22:00

Keynote lecture 1

Chairman: Guo-Qiang Lin (SIOC,CAS & NSFC)

Karl Barry Sharpless (Nobel Laureate 2001, Chemistry, The Scripps Research Institute, USA)

TBA

 

Party in Nanjing High-tech Zone

  
 

Day 4- October 17, 2008– Friday Morning

Session 7:Organic Synthesis III (Hall A)

Chairman: Scott Snyder (Columbia University)

8:30 –9:00

Inivted Lecture 34

Kuiling Ding (SIOC, CAS)

Development of highly efficient chiral catalysts for asymmetric reactions: practical synthesis of chiral drug intermediates

9:00-9:30

Inivted Lecture  35

Robert Franzen (Tampere University of Technology)

Recent advances in the Suzuki cross-coupling reaction of different organoboron derivatives

9:30–10:00

Inivted Lecture 36

Wanzhi Chen (Zhejiang Univ.)

Highly Efficient Catalysts Supported by Multidentate N-Heterocyclic Carbenes for C-C Coupling Reactions

10:00-10:30

 

Inivted Lecture 37  

Chengjian Zhu (Nanjing University)

Asymmetric Reactions Catalyzed by Nitrogen-containing Catalysts

 

10:30–10:50

Coffee Break

Speech from Universal Analytical&Testing Instrument Ltd.15min

 

Chairman: Kunlin Ding (SIOC, CAS)

10:50-11:20

Inivted Lecture 38  

Andrei Yudin (University of Toronto)

Protecting Group-Free Synthesis of Complex Amines

11:20-11:50

Inivted Lecture 39

Feihe Huang (Zhejiang Univ.)

Threaded structures based on crown ether derivative hosts

11:50-12:20

Inivted Lecture 40

Mark R. Biscoe (MIT)

A New Class of Easily Activated Palladium Precatalysts for Facile C=N and C=C “Cross-Coupling Reactions”

 

Day 4- October 17, 2008– Friday Morning

Session 8: Medicinal Chemistry ( Hall B)

Chairman: Wenqing YaoIncyte Co.) / Robert Cherney (Bristol-Myers Squibb Co.)

8:30 –9:00

Inivted Lecture 41

Gui-Dong Zhu Abbott Laboratories, USA

ABT-888 and Back Up, Orally Efficacious Inhibitors of Poly(ADP-ribose) Polymerase (PARP) for the Treatment of Cancer

9:00-9:30

 

Inivted Lecture  42

Matthew Bogyo (Stanford Univ.)

Small molecule activity based probes for diagnostic imaging and drug discovery applications

9:30–10:00

Inivted Lecture 43

Hong Liu ( The Novartis Research Foundation, USA)       

Structure Based Design and Synthesis of Noncovalent Inhibitors of Cathepsin S and Their Applications in Treating Neuropathic Pain

 

10:00-10:30

 

Inivted Lecture 44 

Weizheng (William) Xu (MGI Pharmaceutical, USA)

Design, Synthesis and Biological Evaluation of PARP Inhibitors as Chemosensitizers

10:30–10:50

Coffee Break

 

Medicinal Chemistry Approaches to Tackling Inflammation Disease

10:50-11:20

Inivted Lecture 45 

Li Chen Hoffmann-La Roche

Discovery of VLA4 Antagonists for the Treatment of Autoimmune Diseases

11:20-11:50

Inivted Lecture 46 

Robert J. Cherney (Bristol-Myers Squibb, USA)

Discovery of Potent CCR2 Antagonists

11:50-12:20

Inivted Lecture 47

Yun He (Medical Chemistry Department, Roche R&D Center (China) Ltd)

TBA

 

Day 4- October 17, 2008– Friday Morning

Session 9: Organic Chemistry Process Chemistry (Hall C)

Chairman: Yaping Hong (Princeton GlobalSynthesis LLC)

8:30–9:00

Inivted Lecture 48

Yannis Houpis (Johnson and Johnson PRD)

Carboxylate Directed Pd-Catalyzed Cross Coupling Reactions in the Selective Synthesis of tri-Substituted Aromatics

9:00 –9:30

Inivted Lecture  49

Zhi-Hui (Bruce) Lu  (Boehringer-Ingelheim Pharmaceuticals)

Practical Synthesis Of 2,3-Disubstituted And Polycyclic Indoles

9:30-10:00

Inivted Lecture 50

Jurong Yu (Nanjing PharmaTech)

My experience of doing Process R&D in China: the Story in Nanjing

10:00-10:30

Inivted Lecture 51 

Xudong Wei (Boehringer-Ingelheim Pharmaceuticals)

Practical large scale synthesis of macrocyclic hcv protease inhibitors

1030–10:50

Coffee Break

 

Chairman: Yannis Houpis  (J&J)

10:50-11:20

Inivted Lecture 52  

Yaping Hong (Princeton GlobalSynthesis)

Development of Highly Efficient Chemical Processes for Pharmaceuticals

11:20-11:50

Inivted Lecture 53

Hua Marlon Zhong (Jiangyin PharmaAdvance, Inc.)

TBA

11:50-12:20

Inivted Lecture 54

Yiming Yao (CEO of EnzMed, Nanjing)

Enzymatic synthesis in pharmaceutical development

  

Day 4- October 17–Friday afternoon

Session 10:Organic synthesis III (Huangpu Hall of the Hotel)

Chairman: Wangzhi ChenZhejiang Univ.)

14:00–14:30

Inivted Lecture 55

Zhangjie Shi (Peking Univ.)

Transition-Metal Catalyzed C-H Activation

14:30 –15:00

Inivted Lecture 56  

Lei Liu (Tshinghua Univ.)

Chemical synthesis and modification of proteins

15:00-15: 20

Inivted Lecture 57

Yuhong Zhang (Zhejiang Univ)

Transition metal-catalyzed reactions involving arynes

15:20-15:40

Inivted Lecture 58 

Yanxing Jia (Peking University)

Palladium-catalyzed indole and azaindole syntheis by direct annulation

of electron-poor o-chloro-anilines and chloroaminopyridines with aldehydes

 

Day 4- October 17–Friday afternoon

Session 11: Medicinal Chemistry ( Hall B)

Chairman: Yun He (Medical Chemistry DepartmentRoche R&D Center (China) Ltd)

14:00–14:30

Inivted Lecture 59

Renxiang Tan (Nanjing Univ.)

Symbionts, a Promising Generator of New Drug-like Molecules

14:30 –15:00

Inivted Lecture 60

Ya-Qiu Long (Shanghai Institute of Materia Medica, CAS)

1,6-Naphthyridine-7-carboxamide templated active compounds: switching from hiv-1 integrase inhibitors to anti-tumor agents

15:00-15:20

Inivted Lecture 61

 

Yao-Chang Xu (Novartis AG)

Serotonin antagonist and it’s application in smoking cessation and anti-depression.

15:20–15:40

Inivted Lecture 62 

Chin-Kang Sha (National Tsing-Hua University)

Total Synthesis of (±)-Ottelione A

 

Day 4- October 17–Friday afternoon

Session12: Outsourcing in Chemistry and Drug Development

& 3rd Nanjing International Pharmaceutical Research & Cooperation Conference
 (Hall C)

Chairman: Yuanzan Ye (Acesys Pharmatech)

14:00–14:20

Inivted Lecture 63

           Director of Nanjing High-Tech Zone  

Introduction on Pharmaceutical industry Nanjing High-Tech Zone  

1420 –15:00

Inivted Lecture 64

Stanley Wang (Director, Genscript Corporation)

Outsourcing Biology for Accelerated Discovery

15:00-15:30

Inivted Lecture 65

Dan Liu,,VP, Tripod Biopharmaceutical Group

The CRO trend and the policy of Tripod Biopharmaceuticl Group

1530-1600

Inivted Lecture 66

Charles Ye (CEO, Acesys Pharmatech)

Integrated CRO service in Nanjing

  

15:40–16:00

Coffee Break

  

Day 4-  October 17–Friday afternoon

Keynote Lecture: (Huangpu Hall of the Hotel)

Chairman: Yi Pan (NJU) and Guigen Li (Texas Tech. University)

16:00-16:50

Keynote Lecture 2

 

Avram Hershko (Nobel Laureate 2004, Chemistry, Technion-Israel Institute of Technology, Israel)

TBA

16:50-17:40

Keynote Lecture 3

Aaron Ciechanover (Nobel Laureate 2004, Chemistry, Technion-Israel Institute of Technology, Israel)

TBA

17:40-18:30

Closing Ceremony (Huangpu Hall of the Hotel)

 Yi Pan and Guigen Li

19:00-21:00

Farewell Party (Zijin Hall)

Yi Pan, Rao Rapaka, Guo-Qiang Lin

 

October 18– Saturday

Departure or trip

 

The conference lectures, poster sessions, lunch and accommodation are all located within conference center.

The conference consists of keynote lectures (~50 min, Nobel winners), plenary lectures (~45 min), invited lectures (~30 min), invited talks (~20 min) including discussions and poster sessions. The invited lectures are arranged as three paralleled sessions. Detailed information will be provided in the Scientific Program.

The poster session will be started in the evening of October 15 and remained though out the symposium.

Tour Program

Accompanying person program (mini trip)

From Monday Tue Oct.14, to Friday Oct.17.

Optional Post-Conference Tours A, B, C, D

Three post-conference tours will be organized with reduced rates. For detailed schedule, you can download from the list below.

You are encouraged to email us about your choice to yxcheng@nju.edu.cn in advance.

 

Tour Program Details time Quotation (USD/person)
Tour A: City tour of Nanjing and Visit campus of NJU Morning

Free

Tour B: Chinese traditional family gardens: Nanjing-Yangzhou-Nanjing

Detailed ScheduleEnglish Version   中文版

1 days Tour Package (for a minimum of 20 people) ~$60/p
Tour C: Eastern Venetian City and Chinese classic gardens: Nanjing-Suzhou-Nanjing

Detailed ScheduleEnglish Version    中文版

2 days Tour Package (for a minimum of 20 people) ~$160/p
Tour D: Natural spectacle: Nanjing-Yellow Mountain- Nanjing

Detailed ScheduleEnglish Version   中文版

3 days Tour Package (for a minimum of 20 people) ~$300/p

Remarks: 
1. Tour A is free for all registered participants of ISOSDD2008.

 

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