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Symposium
Program of ISODD2008
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AM Session |
PM Session |
Eve Session |
All Day |
Tue
Oct 14 |
Booth set up by Exhibitors
Registration from 9 am to 7 pm |
Opening
&
Welcome Reception
6 pm to 9 pm |
|
Wed
Oct 15 |
Plenary lectures
&
Exhibition Opens |
Invited lectures
&
Poster Presentations |
Poster Presentations
(workshop) |
Exhibition
Mini Trip (optional) |
Thu
Oct 16 |
Plenary lectures |
Invited lectures
&
Poster Presentations |
Poster Presentations Mini Trip (optional)
(workshop) |
Exhibition
Mini Trip (optional) |
Fri
Oct 17 |
Invited lectures
&
Poster Presentations |
Invited lectures
&
Keynote Speaker |
Closing
&
Conference Dinner |
Exhibition (Tear down from 2 pm)
Mini Trip (optional) |
Sat
Oct 18 |
Departure after breakfast
Optional Post-Conference Tours A, B, C, D (the price is not include the registration fee) |
Schedule
of ISOSDD’08 Technical Program
Day
1-
October 14, 2008, Tuesday
|
8:30 - 18:00 |
Arrival and Registration
(Main hall of
Zhongshan Hotel)
|
|
18:00 - 21:00 |
Welcome |
Opening Ceremony and
Reception Banquet
(First floor of Main
Building)
Guo-Qiang Lin, Rao
Rapaka, Yi Pan |
|
Plenary Lecture 01 |
Chiarman：Mingde
Xia (SAPA)
Stephen Scypinski (Bristol-Myers
Squibb)
Overview of the
Drug Development Process: Assuring Product Quality and Efficacy |
|
|
|
Day 2-
October 15, 2008 – Wednesday morning
|
8:00 - 8:30 |
Welcome
|
Opening Ceremony (Huangpu
Hall of the hotel)
Guo-Qiang Lin, Yi Pan, Jun Chen (President of NJU), Mingde Xia (SAPA) |
Chairman:
Biao
Jiang
(SIOC, CAS)
|
|
8:30 - 9:15 |
Plenary Lecture 02
|
Philip S.
Portoghese (University
of Minnesota)
Ligands that
activate heterodimeric opioid receptors: functional and clinical
relevance |
|
9:15 - 10:00 |
Plenary Lecture 03
|
Xiyan Lu (Shanghai
Institute of Organic Chemistry, CAS)
Paladium(II)
catalyzed addition of arylboronic acids to carbon-heteroatom
multiple bonds. An enantioselective, catalytic
Grignard
type reaction |
|
10:00 - 10:20 |
Coffee Break
|
Chairman:
Lutz F.
Tietze
(Universität Göttingen)
|
|
10:20 - 11:05 |
Plenary Lecture 04 |
Mauricio Futran (Bristol-Myers Squibb)
Knowledge Creation in Pharmaceutical Process Development in the
Context of Global Partnerships |
|
11:05 - 11:50 |
Plenary Lecture 05 |
Chen Li ( Roche-China)
Regulation of
Signals through Protein-Protein Interaction: 15 years and
counting |
|
11:50 - 12:35 |
Plenary Lecture 06 |
Peter W. Schiller (Clinical Research Institute of
Montreal, Canada)
Use of Novel Amino Acid Analogues in the Development of
Peptides as Drugs or Pharmacological Tools |
|
12:35-14：00 |
Lunch
|
Day 2-
October 15, 2008 – Wednesday afternoon
Session 1: Organic Synthesis I ( Hall A)
|
|
Chairman:
Rengxiang Tan (Nanjing Univ.) |
|
14:00–14:30 |
Inivted Lecture 01
|
Dawei Ma (SIOC, CAC)
Amino Acid Promoted
Ullmann-type Coupling Reactions and Their Applications in
Organic Synthesis |
|
14:30 –15:00
|
Inivted
Lecture 02
|
Scott Snyder (Columbia University)
Achieving Synthetic Control When Nature Abandons Selectivity |
|
15:00-15:30 |
Inivted Lecture
03
|
Zhenfeng Xi (Peking Univ.)
Synthesis of multiply substituted pyrrolopyridiens, pyridines
and pyrroles |
|
15:30–16:00 |
Inivted Lecture 04
|
Biao Jiang (Shanghai Institute of Organic Chemistry, CAS)
Synthesis of Chiral Gossypol and Their Derivatives and
Evaluation of Their Anticancer Activity |
|
16:00–16:20 |
Coffee Break |
|
Chairman: Robert Shaw (Texas
Tech University) |
|
16:20–16:50 |
Inivted Lecture 05
|
Lutz F. Tietze
(Universität Göttingen)
A New Approach for a
Selective Treatment of Cancer Based on Prodrugs and Monoclonal
Antibody-Enzyme Conjugates |
|
16:50-17:20 |
Inivted Lecture 06
|
Meixiang Wang (Insitute of Chemsitry, CAS)
Enantioselective Nitrile Biotransformations and Their
Applications in the Synthesis of Natural and Bioactive Compounds
|
|
17:20-17:50 |
Inivted Lecture
07
|
LiMing Zhang
(University of Nevada, Reno)
Au-Catalyzed Cycloaddition Reactions |
Day 2-
October 15, 2008 – Wednesday afternoon
|
Session
2(a):Medicinal Chemistry Approaches to Tackling Cardiovascular
and Metabolic Diseases
(Hall
B) |
|
Chairman: P.K Jadhav (Eli Lilly
& Company, Indianapolis) / Martin Procter (Prosidion, UK) |
|
14:00–14:30 |
Inivted Lecture 08
|
Jiesheng Kang (Sanofi Aventis, USA)
HERG and the LQT
Syndrome: Background, Regulations & Non-Clinical Strategy |
|
14:30 –15:00 |
Inivted Lecture 09
|
Donald Pinto (Bristol-Myers
Squibb Company, USA)
A Next Generation
Oral Anticoagulant: The Discovery of Apixaban, a Potent,
Selective and Orally Bioavailable Factor Xa Inhibitor
|
|
15:00-15:30 |
Inivted Lecture
10
|
P. K. Jadhav (Eli
Lilly & Company, USA)
Orally bioavailable,
nonsteroidal MR antagonist LY2180176 for the treament of
hypertension |
|
15:30-15:50 |
Coffee Break |
|
Session 3: Medicinal
Chemistry Approaches to Tackling Oncology Disease
( Hall B) |
Chairman:
Joe
Shih（Lilly
Research Laboratories, Eli Lilly and Company, USA)
|
|
15:50–16:20 |
Inivted Lecture 11
|
Qun
Li
(Chief
Scientific Officer, Egret Pharma, Shanghai,
China)
Design and
Synthesis of Orally Bioavailable Akt Kinase (PKB) Inhibitors as
Anticancer Agents |
|
16:20–16:50 |
Inivted Lecture 12
|
Jim
Henry
(Discovery
Chemistry Research and Technologies, Lilly Research
Laboratories, Eli Lilly and Company, USA)
Type
II Kinase Inhibitors for the Treatment of Cancer |
|
16:50-17:20 |
Inivted Lecture 13
|
Shawn
Qian
(Associate
Director, Meidcinal Chemistry, Cytokinetics, Inc., USA)
Discovery of
Mitotic Kinesin Inhibitors as Novel Anticancer Agents |
|
17:20-17:50 |
Inivted Lecture
14
|
Joe
Shih
（Lilly
Research Laboratories, Eli Lilly and Company, USA)
The Evolution of
Lilly Oncology: From Cytotoxic Agents (Discovery and Development
of ALIMTAÒ)
to Kinase Inhibitors |
Day 2-
October 15, 2008 – Wednesday afternoon
|
Session 4:
Pharmaceutical Development
( Hall C) |
|
Chairman: Jianji Wang
(Bristol-Myers Squibb Company) |
|
14:00–14:30 |
Inivted Lecture 15
|
Robert Discordia
(Director,
Department of Process Research and Development, Bristol-Myers
Squibb Company)
The
Process Development of an MMP Inhibitor: Development and
Execution of a Crystallization Induced Dynamic Resolution |
|
14:30 –15:00 |
Inivted Lecture 16
|
Jason Huang
(Senior
Research Investigator II, Department of Analytical Research and
Development,
Bristol-Myers Squibb Company)
Analytical Role in Pharmaceutical Development and GMP Compliance |
|
15:00-15:30 |
Inivted Lecture
17
|
Joan
Ruan (Group
Leader, Department of Analytical Research and Development,
Bristol-Myers Squibb Company)
Forced Degradation Strategy |
|
15:30-16:00 |
Inivted Lecture
18
|
Thomas Colacot (Johnson Matthey Catalyst)
Highly Active,
Air-Stable Pd Catalysts for Challenging Cross-Coupling Reactions |
|
16:00–16:20 |
Coffee Break |
|
|
Chairman: Mingde Xia (SAPA) |
|
16:20–16:50 |
Inivted Lecture 19
|
Jianji Wang
(Senior
Research Investigator II, Department of Process Research and
Development, Bristol-Myers Squibb Company)
Pharmaceutical Process
Research and Development |
|
16:50-17:20 |
Inivted Lecture 20
|
Xiongwei Shi
(United Pharmatech)
Sundia's Strategies and Steps towards Meeting Client's
Requirements for Outsourcing Services |
|
17:20-17:50 |
Inivted Lecture 21
|
Jay (Jiefei) Cheng (Otsuka Maryland Medicinal
Laboratories Inc, USA)
TheYin and Yang of
theFattyAcid Oxidation Modulation |
|
17:50-19:00 |
Dinner
|
|
19:00-22:00 |
Posters
|
Day 3-
October 16, 2008– Thursday Morning
Plenary Lecture:
(Huangpu Hall of the Hotel)
|
Chairman: Zhenfeng Xi
(Peking Univ.)
|
|
8:00 – 8:45 |
Plenary Lecture 07
|
Kevin Burgess
(Texas A&M University)
Libraries of
Bivalent Peptidomimetics for Mimicking or Disrupting
Protein-Protein Interactions |
|
8:45–9: 30 |
Plenary Lecture 08
|
Guo-Qiang Lin
(SIOC, CAS and NSFC)
New Synthetic
Methodologies and Their Utilities in the Synthesis of Bio-active
Products |
|
9:30 -10:15 |
Plenary Lecture 09
|
Bruce Lipshutz
(University of California, Santa Barbara)
Green Chemistry
Using "Designer" Surfactants. Just Add Water |
|
10: 15 – 10:45 |
Coffee Break
|
|
|
Chairman
|
Dawei Ma (SIOC, CAS) |
|
10:45 - 11:30 |
Plenary Lecture 10
|
Rene Imwinkelried (Schering-Plough, USA)
Chemical Process Scale-Up Opportunities |
|
11:30 -12:15 |
Plenary
Lecture 11 |
Ralph P Volante (Lushi Tan) (Process Research,
Merck)
Asymmetric
hydrogenation/transfer hydrogenation a powerful strategy for
drug synthesis |
|
12:15– 14:00 |
Lunch
|
Day 3-
October 16–Thursday afternoon
|
Session 5: General
Medicinal
Chemistry (Hall
A) |
|
Chairman: Qidong You (China
Pharmaceutical
University)/Jianhe
Deng
(GlaxoSmithKline. Co) |
|
14:00–14:30
|
Inivted Lecture 22
|
Jianhe Deng
(GlaxoSmithKline. Co)
Encoded Library
Technology: A New Methodology for Lead Discovery
|
|
14:30 –15:00 |
Inivted Lecture 23
|
Robert Shaw
(Texas Tech University)
Antibiotic
resistance in bacteria: novel metalloenzyme inhibitors |
|
15:00-15:30 |
Inivted Lecture
24
|
Ao Zhang (Shanghai
Institute of Materia Medica, CAS)
Multi-Strategy for
Design of Dopamine D1 & Serotonin 5-HT1A Receptor Ligands. |
|
15:30–16:00 |
Inivted Lecture 25
|
Qidong You (China Pharmaceutical University)
Conformation-based design of camptothecin analogues as potent
DNA topoisomerase I inhibitors |
Day 3-
October 16–Thursday afternoon
|
Session 2(b)
:Medicinal Chemistry Approaches to Tackling Cardiovascular and
Metabolic Diseases
(Hall
B) |
|
Chairman: P.K Jadhav (Eli Lilly
& Company, Indianapolis) / Martin Procter (Prosidion, UK) |
|
14:00–14:30 |
Invited Lecture 26
|
Wenqing Yao (Incyte
Corporation, USA)
Discovery of Potent and Selective 11ßHSD1 Inhibitors: Scaffold
Hoping Approach for Novel Lead Generation Based on Medchem
Intuition |
|
14:30 –15:00 |
Inivted Lecture 27
|
Gang Zhao (Abbott, USA)
Discovery and SAR development of thienopyridones: A class of
small molecule AMPK activators |
|
15:00-15:30 |
Inivted Lecture
28
|
Martin Procter (Prosidion, UK)
Design and synthesis of orally bioavailable Glucokinase
activators |
|
15:30–16:00 |
Inivted Lecture 29
|
Hongke Liu (Nanjing
Normal University)
Interactions of
Organometallic Ruthenium Arene anticancer Complexes with DNA |
Day 3-
October 16–Thursday afternoon
|
Session 6: Chemistry
Application in Pharmaceutical Industry
( Hall C) |
Chairman:
Hua Marlon,
Zhong
(Jiangyin PharmaAdvance, Inc.)
|
|
14:00–14:30 |
Inivted Lecture 30
|
Joseph M.
Salvino
(Director,
Hit to Lead Chemistry, Cephalon, Inc)
Practical
Approaches toward Lead Finding and Lead Optimization Library
Synthesis |
|
14:30 –15:00 |
Inivted Lecture 31
|
Yonghui Wang
(Medicinal Chemistry, Oncology CEDD, GlaxoSmithKline, USA)
7TM Receptor
Antagonists: Lead Discovery Strategy and Case Studies |
|
15:00-15:30 |
Inivted Lecture
32
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